Open AccessAlpha‐1 anti‐trypsin and CD30 expression occur in parallel in activated T cells
Author(s) -
BASHIR M. S.,
JONES D. B.,
WRIGHT D. H.
Publication year - 1992
Publication title -
clinical & experimental immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.329
H-Index - 135
eISSN - 1365-2249
pISSN - 0009-9104
DOI - 10.1111/j.1365-2249.1992.tb06484.x
Subject(s) - trypsin , cd30 , biology , lymphoma , microbiology and biotechnology , t cell , immunology , immune system , biochemistry , enzyme
SUMMARY We have performed an immunohistochemical study of immunoblastic T cell lymphoma and enteropathy‐associated T cell lymphoma for alpha‐1 anti‐trypsin and CD30. Cytoplasmic staining for α1 anti‐trypsin is present in the malignant cells in both types of T cell neoplasm which also express CD30, a marker of lymphoid activation. Peripheral blood T lymphocytes on stimulation with mitogen also show granular cytoplasmic expression of α1 anti‐trypsin. Time course studies show that this parallels the expression of CD30. α1 anti‐trypsin expression appears therefore to be associated with activation in T cells. Further studies of sub‐fractionated T lymphocytes in vitro suggest that the expression of α1 anti‐trypsin on activation is not restricted to an individual lymphocyte subset.