Open AccessAutoantibodies against cyclophilin in systemic lupus erythematosus and Lyme disease
Author(s) -
KRATZ A.,
HARDING M. W.,
CRAFT J.,
MACKWORTHYOUNG C. G.,
HANDSCHUMACHER R. E.
Publication year - 1992
Publication title -
clinical & experimental immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.329
H-Index - 135
eISSN - 1365-2249
pISSN - 0009-9104
DOI - 10.1111/j.1365-2249.1992.tb05862.x
Subject(s) - immunology , autoantibody , antibody , cyclophilin , cyclophilin a , lyme disease , peptidylprolyl isomerase , medicine , biology , virology , microbiology and biotechnology , isomerase , gene , biochemistry
SUMMARY Autoantibodies against cyclophilin, a cyclosporin A binding protein, were detected in sera of 29 of 46 (63%) patients with systemic lupus erythematosus and 14 of 40 (35%) Lyme disease patients. The antibodies are directed against the denatured form of both the major and minor isoform of cyclophilin and, can be demonstrated in Western blots. Some first‐degree relatives of lupus patients also express these antibodies. They are specific for cyclophilin and are not the consequence of hypergammaglobulinaetnia. Four monoclonal IgM antibodies from a patient with lepromatous leprosy also bound to cyclophilin. The generation of these antibodies may be of special interest because they are against a protein involved in the control of the immune system not known to be directly associated with DNA or RNA.