Open AccessInduction of endogenous retroviral gene product (SU) as an acute‐phase protein by IL‐6 in murine hepatocytes
Author(s) -
ITOH Y.,
MARUYAMA N.,
KITAMURA M.,
SHIRASAWA T.,
SHIGEMOTO K.,
KOIKE T.
Publication year - 1992
Publication title -
clinical & experimental immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.329
H-Index - 135
eISSN - 1365-2249
pISSN - 0009-9104
DOI - 10.1111/j.1365-2249.1992.tb03087.x
Subject(s) - endogeny , immunology , gene , biology , gene product , virology , medicine , gene expression , genetics , endocrinology
SUMMARY The effect of Lps locus and IL‐6 on the production of SU (previously termed gp70), a mouse endogenous retroviral gene product, was studied. Back‐cross studies using the progeny between (NZB × C3H/HeJ)F1 and C3H/HeJ mice indicate that the basal level of SU is not associated with the Lps locus on chromosome 4. Lipopolysaccharide (LPS) mitogen response‐negative mice did not show the enhancement of serum SU production after LPS injection. Spleen cells from LPS‐mitogen response‐positive but not from negative mice showed increase of IL‐6 synthesis in the presence of LPS. Since IL‐6 may be involved in the production of serum SU, we tested the effect of IL‐6 in a primary hepatocyte culture system. SU production was clearly enhanced in the presence of recombinant IL‐6, indicating that IL‐6 induced by LPS can enhance the expression of retroviral genome.