Open AccessExpression of ICAM‐1 (CD54) on normal and leukaemic B cells: implication for the mixed lymphocyte reaction
Author(s) -
PADROS M. R.,
NOLI M. I.,
FAINBOIM L.
Publication year - 1992
Publication title -
clinical & experimental immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.329
H-Index - 135
eISSN - 1365-2249
pISSN - 0009-9104
DOI - 10.1111/j.1365-2249.1992.tb03082.x
Subject(s) - mixed lymphocyte reaction , lymphocyte , immunology , stimulation , biology , antibody , microbiology and biotechnology , immune system , t cell , endocrinology
SUMMARY Peripheral blood normal B lymphocytes were found to be poor stimulators in the mixed lymphocyte reaction (MLR), in contrast to normal activated B cells which were strong stimulators. This increased capacity to stimulate a strong MLR correlated with an increased expression of the ICAM‐1 (CD54) molecule on the surface of these cells. Similarly, the capacity of leukaemic B cells to induce an allogenic stimulation in the MLR was limited to the ICAM‐1 (CD54) positive leukaemic cells. The ability of normal activated or leukaemic B cells to induce an M LR was blocked by antibodies directed against ICAM‐1.