Open AccessHost and bacterial factors control the Mycobacterium avium ‐induced chronic peritoneal granulocytosis in mice
Author(s) -
APPELBERG R.,
PEDROSA J. M.,
SILVA M. T.
Publication year - 1991
Publication title -
clinical & experimental immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.329
H-Index - 135
eISSN - 1365-2249
pISSN - 0009-9104
DOI - 10.1111/j.1365-2249.1991.tb05620.x
Subject(s) - granulocytosis , virulence , microbiology and biotechnology , biology , mycobacterium avium complex , immunology , immune system , ratón , virology , granulocyte , biochemistry , gene
SUMMARY Persistent peritoneal granulocytosis and elevated macrophage counts have been found in nine mouse strains from 8 to 90 days after infection with Mycobacterium avium . Peritoneal granulocylosis was higher in M. avium ‐resistant BALB/c. Bcg r (C.D2) mice, compared with congenic M. avium ‐susceptible BALB/c ( Bcg b ) animals. Although maximal granulocytosis values were not related to virulence of the inocula, the kinetics of the granulocytic response varied with the virulence of M. arium . Following infections by avirulent (rough) strains of M. avium , the peritoneal granulocytosis progressively declined in BALB/c and C3H/He mice. A similar decline in granulocyte number was observed in resistant C3H/He mice infected with virulent M. avium (smooth transparent strain). In both instances the decline in the peritoneal granulocytosis was associated with a progressive elimination of the inoculum. In the susceptible BALB/c mice, virulent M. avium strains induced progressive infection accompanied with a rapid decline in granulocyte number, whereas the infection with attenuated M. avium , which caused a chronic infection, induced persistent granulocytosis. The ability to recruit granulocytes following the intraperitoneal inoculation of a phlogistic substance (casein hydrolysate) was decreased in infected susceptible but not in infected resistant mice at 90 days of infection with virulent M. avium .