Open AccessImbalance of CD4 + CD45R + and CD4 + CD29 + T helper cell subsets in patients with atopic diseases
Author(s) -
SCHAUER U.,
JUNG T.,
HEYMANNS J.,
RIEGER C. H. L
Publication year - 1991
Publication title -
clinical & experimental immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.329
H-Index - 135
eISSN - 1365-2249
pISSN - 0009-9104
DOI - 10.1111/j.1365-2249.1991.tb05582.x
Subject(s) - immunology , cd4 t cell , t helper cell , medicine , t cell , immune system
SUMMARY To evaluate the proportion of helper cell subsets we studied 18 children with atopic dermatitis, 30 patients with asthma. 27 healthy age‐matched controls aged 1 to 17 years and 11 atopic controls without symptoms related to atopy, aged 9–22 years. Lymphocytes were isolated from heparinized peripheral blood and the proportion of CD4 + CD29 + and CD4 + CD45R + cells was determined by double‐labelling immunofluorescence. Children with atopic dermatitis yielded a significantly ( P <0.0l) higher proportion of CD4 + CD45R + (median 75%) cells compared with normal controls (median 66.6%). whereas the proportion of CD4 + CD29 + cells was significantly (P<0.0l) lower in patients with atopic dermatitis (median 204 versus 29.6%). Interestingly, the percentage of CD4 + CD45R + cells shows an age‐dependent decline (r= ‐0.67, P <0.0l) in the control group, which is not found in the patient group.