Open AccessHuman colostrum contains an activity that inhibits the production of IL‐2
Author(s) -
HOOTON J. W. L.,
PABST H. F.,
SPADY D. W.,
PAETKAU V.
Publication year - 1991
Publication title -
clinical & experimental immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.329
H-Index - 135
eISSN - 1365-2249
pISSN - 0009-9104
DOI - 10.1111/j.1365-2249.1991.tb02963.x
Subject(s) - phytohaemagglutinin , colostrum , jurkat cells , cytotoxic t cell , biology , immune system , lymphokine , immunology , concanavalin a , microbiology and biotechnology , t cell , endocrinology , medicine , antibody , in vitro , biochemistry
SUMMARY The effect of human colostrum on T cell immune function was investigated. Colostrum inhibited the proliferation of human T cells activated by allogeneic, concanavalin A (Con A) or phytohaemagglutinin (PHA) stimulation. Colostrum also inhibited the production of IL‐2 by Con A‐activated human peripheral blood T cells and by Con A‐activated Jurkat cells, a human T lymphoma line. Similarly, human colostrum inhibited the production of IL‐2 by EL4 cells, a murine thymoma line, when stimulated with phorbol myristate acetate. The inhibitory activity was not cytotoxic and could not be neutralized by antibody to transforming human growth factor β.