Open AccessAutoantibodies against Forssman glycolipids in Graves' disease and Hashimoto's thyroiditis
Author(s) -
ARIGA T.,
YOSHIDA T.,
MIMORI T.,
YU R. K.
Publication year - 1991
Publication title -
clinical & experimental immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.329
H-Index - 135
eISSN - 1365-2249
pISSN - 0009-9104
DOI - 10.1111/j.1365-2249.1991.tb02957.x
Subject(s) - autoantibody , thyroiditis , immunology , medicine , anti thyroid autoantibodies , graves' disease , disease , antibody , pathology
SUMMARY Sera from patients with Graves’ disease and Hashimoto's thyroiditis have been shown to react with the Forssman glycolipid antigen (Gb5) using the techniques of high performance thin‐layer chromatography (HPTLC) immunostaining and ELISA. Human monoclonal antibodies (MoAbs) have been prepared by fusion of human myeloma with peripheral lymphocytes from patients with Graves’ disease. A MoAb, TRMo‐4, reacted strongly and specifically with Gb5. These results suggest that anti‐Forssman antibody may be involved in the pathogenesis of these autoimmune diseases. The detection of anti‐Forssman glycolipid antibody may provide a useful means for clinical diagnosis and therapy.