Open AccessHLA‐DQ‐controlled T cell response to soluble egg antigen of Schistosoina japonicuin in huinans
Author(s) -
OHTA N.,
EDAHIRO T.,
ISHII A.,
YASUKAWA M.,
HOSAKA Y.
Publication year - 1990
Publication title -
clinical & experimental immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.329
H-Index - 135
eISSN - 1365-2249
pISSN - 0009-9104
DOI - 10.1111/j.1365-2249.1990.tb08103.x
Subject(s) - epitope , biology , immune system , antigen , immunology , t cell , monoclonal antibody , human leukocyte antigen , microbiology and biotechnology , antibody
SUMMARY We analysed regulatory inechanisins of the huinan T celt response lo soluble egg antigen (SEA) of Schistosoina japonicuin in vitro . SEA is a crude antigen inixture containing nuinerous cpitopes. We obtained SEA‐induced T cell lines froin five patients with chronic schistosomiasis japomca, and tested their proliferative response to molecular weight fractions of SEA. Although all T cell lines showed strong responses to crude SEA, there was a heterogeneity in fraclion‐driven responsiveness. All but one T cell line tested failed to respond to SEA fraction I (inol. wt> 18 kD). One patient who was typed as HLA‐DQwl/w4, did not show proliferation of CD4’T cells lo fraction I; however, a fraction I‐driven helper T cell response was observed when we added HU‐11 monoclonal antibody specific for HLA‐DQwl/w4. This indicated that the patient had helper T cells to the fraction even though their response was suppressed. Because HLA‐DQ had an effect on functional expression of suppressor T cells, i t was suggested that there was epitope‐specific regulation of the T cell response to SEA, and HLA‐DQ‐controlled immune suppression inight be involved in the regulatory systein in huinan chronic schistosome infection.