Open AccessDepressed lymphocyte transformation and the role of prostaglandins in atopic dermatitis
Author(s) -
JAKOB T.,
HUSPITH B.N.,
LATCHMAN Y.E.,
RYCROFT R.,
BROSTOFF J.
Publication year - 1990
Publication title -
clinical & experimental immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.329
H-Index - 135
eISSN - 1365-2249
pISSN - 0009-9104
DOI - 10.1111/j.1365-2249.1990.tb08099.x
Subject(s) - atopic dermatitis , immunology , peripheral blood mononuclear cell , immunoglobulin e , immune system , concanavalin a , lymphocyte , monocyte , prostaglandin e , medicine , biology , in vitro , endocrinology , antibody , biochemistry
SUMMARY We have shown that peripheral blood mononuclear cells (PBMC) from patients with atopic dermatitis have a reduced in vitro proliferative responsiveness to concanavalin A when compared with non‐atopic controls, Addition of the cyclo‐oxygenase inhibitor indomethacin caused a significant enhancement of the mitogen response in the patients, indicating a suppressive effect of cyclooxygenase products. We have further demonstrated increased levels of prostaglandin E 2 in the supernatants of the PBMC cultures and mereased levels of IgE immune complexes in the sera of the aotpic dermatitis patients and therefore hypothesize that IgE immune complexes may cause increased monocyte production of prostaglandins which in turn appears to be responsible for a reduced lymphocyte proliferation.