Open AccessActivation of lymphocytes after platelet allotransfusion possessing only class I MHC product
Author(s) -
PÓCSIK É.,
MIHALIK R.,
GYÓDI É.,
RÉTI M.,
PÁLÓCZI K.,
PETRÁNYI G. G.,
BENCZÚR M.
Publication year - 1990
Publication title -
clinical & experimental immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.329
H-Index - 135
eISSN - 1365-2249
pISSN - 0009-9104
DOI - 10.1111/j.1365-2249.1990.tb05411.x
Subject(s) - platelet activation , priming (agriculture) , mhc class ii , platelet , immunology , biology , transferrin receptor , t cell , antigen , receptor , cell adhesion molecule , microbiology and biotechnology , major histocompatibility complex , monoclonal antibody , antibody , immune system , biochemistry , botany , germination
SUMMARY After platelet allotransfusion, we found a characteristic increase in the expression of interleukin‐2 receptor, dipeptydilpeptidase IV (CD26), activation‐inducer molecule (AIM, CD69) and transferrin receptors (CD71) on day 3 indicating that important functional molecules expressed on the activation of lymphocytes by allogeneic platelets. At the same time, no consistent increase of other activation molecules such as Ki‐1 (CD30), intercellular adhesion molecule (ICAM‐1, CD54) and Ki‐24 (CDw70) antigen expression was detected, probably as a result of the selective activation of some lymphocyte subsets. In order to obtain further evidence for the in vivo activation triggered by allogeneic platelets, a subsequent step of T cell activation towards differentiation was investigated with monoclonal antibodies to leucocyte common antigens. A sharp expression of the UCHL1, coupled with a decrease of the CD45R molecule was detected on day 7 or 14, suggesting a T cell priming.