Open AccessMultiple infusions of human intravenous immunoglobulin in chimpanzees do not lead to immune elimination
Author(s) -
LEIBL H.,
WOLF H. M.,
EDER G.,
MANNHALTER J. W.,
EIBL M. M.
Publication year - 1990
Publication title -
clinical & experimental immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.329
H-Index - 135
eISSN - 1365-2249
pISSN - 0009-9104
DOI - 10.1111/j.1365-2249.1990.tb05355.x
Subject(s) - immune system , antibody , immunology , biology , cd8 , immunoglobulin g
SUMMARY Administration of human i.v. immunoglobulins was shown to lead to a permanent increase in IgGl and IgG2 levels in chimpanzees. Half‐lives of human IgG1 and IgG2 in chimpanzees were comparable to those found in humans, and no signs of immune elimination were observed. Furthermore, long‐term treatment of chimpanzees had no effect on the percentage of immunoregulatory T cells (CD2 + , CD4 + and CD8 + T cells) as determined by FACS analysis. In addition, serum IgM levels in chimpanzees were found to be comparable to those in humans, whereas the chimpanzees' IgG levels are slightly elevated due to higher concentrations of IgG2 and, in particular, IgG4.