Open AccessThe effect of treatment with interferon‐gamma on type II collagen‐induced arthritis
Author(s) -
NAKAJIMA H.,
TAKAMORI H.,
HIYAMA Y.,
TSUKADA W.
Publication year - 1990
Publication title -
clinical & experimental immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.329
H-Index - 135
eISSN - 1365-2249
pISSN - 0009-9104
DOI - 10.1111/j.1365-2249.1990.tb05353.x
Subject(s) - interferon gamma , arthritis , collagen induced arthritis , immunology , recombinant dna , medicine , type ii collagen , interferon , therapeutic effect , cytokine , endocrinology , chemistry , biochemistry , gene
SUMMARY We have investigated the effects of recombinant murine interferon‐gamma (rIFN‐γ) on type II collagen‐induced arthritis (CA) in DBA/1 mice. Therapeutic as well as prophylactic treatment with subcutaneous rIFN‐γ, at 10 5 U/mouse six times a week, inhibited the development of CA without any obvious side effects. The accompanying suppression of anti‐CII antibody responses may partly explain the inhibition of CA by rIFN‐γ. The possible role of the anti‐inflammatory effect of systemic IFN‐γ in the inhibition of CA is discussed.