Open AccessImmunoregulatory CD4 + CD45R + suppressor/inducer T lymphocyte subsetsand impaired cell‐mediated immunity in patients with Down's syndrome
Author(s) -
RAZIUDDIN S.,
ELAWAD M. E.
Publication year - 1990
Publication title -
clinical & experimental immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.329
H-Index - 135
eISSN - 1365-2249
pISSN - 0009-9104
DOI - 10.1111/j.1365-2249.1990.tb05128.x
Subject(s) - phytohaemagglutinin , inducer , cd8 , immunology , biology , t lymphocyte , concanavalin a , cellular immunity , t cell , cytotoxic t cell , lymphocyte , immune system , microbiology and biotechnology , genetics , in vitro , gene
SUMMARY The monoclonal antibodies 2H4 and 4B4 allow CD4 + and CD8 + T lymphocytes to be subdividedinto CD45R + and CDW29 + functional subpopulations. The CD4 + CD45R + lymphocytes aredesignated as suppressor/inducer and CD4 + CDW29 + as helper/inducer subsets. Peripheral bloodlymphocytes from 19 patients with Down's syndrome and 19 age‐ and sex‐matched normal controlswere analysed for the CD45R + and CDW29 + subsets from the CD4 + and CD8 + T lymphocytes. Thepercentage of CD4 + CD45R + cells (suppressor inducer) was markedly increased and of CD4 + CDW29 + cells (helper/inducer) decreased in all patients with Down's syndrome. In contract, thepercentage of CD8 + CD45R + and CD8 + CDW29 + subsets showed no major differences betweenpatients with Down's syndrome and normal controls. Moreover, an alteration in the CD4 + andCD45R + and CD4 + CDW29 + T cell subsets was accompanied by a markedly reduced proliferativeresponse to phytohaemagglutinin and concanavalin A stimulation of the CD4 + T lymphocytes. Thus, a deficiency exists in patients with Down's syndrome in the CD4 + CDW29 + helper/inducerT cell subset which may contribute to their impaired cell‐mediated immunity.