Open AccessImmune activation and T cell subset abnormalities in circulation of patients with recently diagnosed type I diabetes mellitus
Author(s) -
ALKASSAB A. S.,
RAZIUDDIN S.
Publication year - 1990
Publication title -
clinical & experimental immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.329
H-Index - 135
eISSN - 1365-2249
pISSN - 0009-9104
DOI - 10.1111/j.1365-2249.1990.tb03329.x
Subject(s) - immune system , diabetes mellitus , immunology , medicine , type 1 diabetes , immunopathology , type 2 diabetes mellitus , endocrinology
SUMMARY The peripheral blood lymphocytes from patients with insulin‐dependent diabetes mellitus (IDDM) and healthy controls were analysed for the HLA‐DR + , interleukin‐2 receptor‐positive (IL‐2R + ) activating antigens, and for CD45R + and CDw29 + subsets from the purified CD4 + and CD8 + T cell populations. Patients with IDDM had an increased percentage of HLA‐DR + and IL‐2R + cells in both CD4 + and CD8 + T cells. However, the percentage of CD4 + CD45R + suppressor/inducer T cells were decreased and CD4 + CDw29 + helper/inducer T cells increased in all patients with IDDM, compared with healthy controls. Thus, IDDM patients exhibit a deficiency in the CD4 + CD45R + suppressor/inducer T cell subsets, which is probably related to the autoimmune phenomenon in this disease. In contrast, the percentage of CD8 + CD45R + and CD8 + CDw29 + T cell subsets showed no major differences between patients with IDDM and controls. An alteration in the CD4 + CD45R + and CD4 + CDw29 + T cell subsets appears to be a characteristic feature, and may relate to the impaired cell‐mediated immunity in IDDM. These data provide new evidence for T cell dysregulation in IDDM.