Pyoderma gangrenosum in association with Janus kinase 2 ( JAK2V617F ) mutation | Zendy

Palanivel J. A. | Zendy; Macbeth A. E. | Zendy; Levell N. J. | Zendy

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Pyoderma gangrenosum in association with Janus kinase 2 ( JAK2V617F ) mutation

Author(s) -

Palanivel J. A.,

Macbeth A. E.,

Levell N. J.

Publication year - 2013

Publication title -

clinical and experimental dermatology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.587

H-Index - 78

eISSN - 1365-2230

pISSN - 0307-6938

DOI - 10.1111/j.1365-2230.2012.04375.x

Subject(s) - pyoderma gangrenosum , janus kinase , pathogenesis , janus , janus kinase 2 , medicine , mutation , cancer research , immunology , biology , kinase , genetics , gene , cytokine , disease , materials science , nanotechnology

Summary Pyoderma gangrenosum (PG) commonly occurs in association with various haematological and inflammatory disorders. We report a new association, a Janus kinase (JAK)2 mutation, in a 63‐year‐old patient with PG. We hypothesise that PG occurs by direct activation of JAK along with signal transducers and activators of transcription (STAT), a common mechanism involved in the pathogenesis of inflammatory and haematological diseases.

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