Premium
Pyoderma gangrenosum in association with Janus kinase 2 ( JAK2V617F ) mutation
Author(s) -
Palanivel J. A.,
Macbeth A. E.,
Levell N. J.
Publication year - 2013
Publication title -
clinical and experimental dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.587
H-Index - 78
eISSN - 1365-2230
pISSN - 0307-6938
DOI - 10.1111/j.1365-2230.2012.04375.x
Subject(s) - pyoderma gangrenosum , janus kinase , pathogenesis , janus , janus kinase 2 , medicine , mutation , cancer research , immunology , biology , kinase , genetics , gene , cytokine , disease , materials science , nanotechnology
Summary Pyoderma gangrenosum (PG) commonly occurs in association with various haematological and inflammatory disorders. We report a new association, a Janus kinase (JAK)2 mutation, in a 63‐year‐old patient with PG. We hypothesise that PG occurs by direct activation of JAK along with signal transducers and activators of transcription (STAT), a common mechanism involved in the pathogenesis of inflammatory and haematological diseases.