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Pagetoid reticulosis in a prepubescent boy successfully treated with photodynamic therapy
Author(s) -
Mendese G. W.,
Beckford A.,
Krejci N.,
Mahalingam M.,
Goldberg L.,
Gilchrest B. A.
Publication year - 2012
Publication title -
clinical and experimental dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.587
H-Index - 78
eISSN - 1365-2230
pISSN - 0307-6938
DOI - 10.1111/j.1365-2230.2012.04352.x
Subject(s) - dermatopathology , medicine , dermatology , library science , computer science
Summary Pagetoid reticulosis or Woringer–Kolopp disease (WKD) is a rare variant of mycosis fungoides, consisting of localized patches or plaques containing intraepidermal proliferations of neoplastic T cells in a pagetoid distribution (similar to that of the adenocarcinomatous cells found in Paget disease of the nipple), which typically affects middle‐aged and elderly men. We report a trial of photodynamic therapy (PDT) with topical aminolaevulinic acid (ALA), carried out on a 10‐year‐old boy with a solitary lesion of WKD on his foot, to avoid the long‐term problems associated with the typical treatments for WKD of surgery and/or local irradiation. The plaque progressively flattened during treatment, and after nine PDT sessions over 13 months, the patient was clinically free of disease. PDT may be a viable alternative to surgery and local irradiation for localized cutaneous T‐cell lymphoma, including WKD, especially in younger patients.