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Expression pattern of REIC/Dkk‐3 in mouse squamous epithelia
Author(s) -
Kataoka K.,
Du G.,
Maehara N.,
Murata H.,
Sakaguchi M.,
Huh N.
Publication year - 2012
Publication title -
clinical and experimental dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.587
H-Index - 78
eISSN - 1365-2230
pISSN - 0307-6938
DOI - 10.1111/j.1365-2230.2011.04301.x
Subject(s) - immortalised cell line , epithelium , cell culture , gene expression , cancer research , epidermis (zoology) , gene , biology , pathology , microbiology and biotechnology , medicine , anatomy , genetics
Summary The REIC/Dkk (reduced expression in immortalized cells/Dickkopf‐3) gene was originally identified as a tumour‐suppressor gene with reduced expression in immortalized cells, cancer‐cell lines and tumour tissues. Of the four members of the Dkk family, the REIC/Dkk‐3 protein is unique in terms of DNA sequence, expression profiles and biological functions. In this study, we investigated and compared the expression patterns of the REIC/Dkk‐3 protein in mouse squamous epithelia. Expression of REIC/Dkk‐3 in the back skin was localized to the upper layer of the interfollicular epidermis, and the inner root sheath of hair follicles. Expression of REIC/Dkk‐3 was detected in the ear skin, oral mucosa, tongue, oesophagus, uterine cervix, footpad and tail skin, but not in the cornea. Interestingly, expression was localized to the upper layers of these epithelial tissues. The physiological function of REIC/Dkk‐3 is still unclear, but our detailed observation highlight its unique expression pattern in squamous epithelia.