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Autologous transplantation of bone marrow–derived mesenchymal stem cells: a promising therapeutic strategy for prevention of skin‐graft contraction
Author(s) -
Xu Y.,
Huang S.,
Fu X.
Publication year - 2012
Publication title -
clinical and experimental dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.587
H-Index - 78
eISSN - 1365-2230
pISSN - 0307-6938
DOI - 10.1111/j.1365-2230.2011.04260.x
Subject(s) - medicine , mesenchymal stem cell , scars , transplantation , contraction (grammar) , surgery , stem cell , bone marrow , pathology , biology , genetics
Summary Hypertrophic scars resutl from abnormal healing of severe burns, and are characterized by loss of the original structure and function of the skin. Transplantation of autologous split skin is the preferred treatment after scar excision; however, there will be some unavoidable degree of contraction within the grafts. To our knowledge, it is very rare that bone marrow‐derived mesenchymal stem cells (BM‐MSCs) have been used for the treatment of skin‐graft contraction. However, in our clinics, we found that during a 2‐year follow‐up analysis, areas treated with autologous BM‐MSCs combined with transplantation of split skin were less likely to have contraction of the skin grafts than areas treated with skin grafts alone. This result indicates that BM‐MSCs may be a potential and promising treatment to prevent contraction of skin grafts.