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Mesna‐induced photodistributed dermatosis
Author(s) -
Lin C. Y.,
Keefe M.
Publication year - 2012
Publication title -
clinical and experimental dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.587
H-Index - 78
eISSN - 1365-2230
pISSN - 0307-6938
DOI - 10.1111/j.1365-2230.2011.04233.x
Subject(s) - mesna , medicine , cyclophosphamide , culprit , dermatology , hemorrhagic cystitis , rash , wegener granulomatosis , chemotherapy , surgery , ifosfamide , vasculitis , disease , etoposide , myocardial infarction
Summary We present the case of a 41‐year‐old man who developed a photodistributed eruption 1 month after being started on 2‐mercaptoethane sulfonate sodium (mesna) for treatment of cyclophosphamide‐induced haemorrhagic cystitis. The patient had a background history of Wegener granulomatosis, and had been taking cyclophosphamide at a stable dose of 150 mg daily for the previous 3 years. Complete resolution of the rash occurred within 8 weeks of cessation of mesna. This is the first reported case, to our knowledge, of mesna‐induced photodistributed dermatosis. Early recognition of this condition will ensure prompt cessation of the culprit medication, and consideration of alternative management of haemorrhagic cystitis.