Premium
Reticulohistiocytosis: different dermatoscopic faces and a good response to methotrexate treatment
Author(s) -
Kaçar N.,
Tasli L.,
Argenziano G.,
Demirkan N.
Publication year - 2010
Publication title -
clinical and experimental dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.587
H-Index - 78
eISSN - 1365-2230
pISSN - 0307-6938
DOI - 10.1111/j.1365-2230.2009.03738.x
Subject(s) - dermatoscopy , reticular connective tissue , medicine , xanthoma , dermatology , pathology , histiocyte , dermatofibroma , melanoma , immunohistochemistry , cancer research
Summary The reticulohistiocytoses are a rare group of non‐Langerhans cell histiocytic disorders. Recently, dermatoscopic features have been reported for some of the xanthomatous disorders. We report a case of diffuse cutaneous reticulohistiocytosis with 29 reticulohistiocytomas. On dermatoscopy of these lesions, we saw three typical features: a homogeneous pattern with various shades of yellow (defined previously as a ‘setting‐sun’ pattern), brown reticular structures, and central white scar‐like patches and streaks. The setting‐sun pattern was most commonly seen in combination with brown reticular structures. In four lesions, brown reticular structures surrounded a central white scar‐like patch resembling that of a dermatofibroma. However, the presence of the setting‐sun pattern in the background gave a different hue to that of the peripheral network seen in a dermatofibroma. A marked clinical improvement was associated with 6 months of systemic methotrexate treatment. Dermatoscopy may aid in the diagnosis of xanthomatous diseases. For this patient, methotrexate was beneficial.