Premium
Localized bullous pemphigoid in a patient with primary lymphoedema tarda
Author(s) -
Perez A.,
Clements S. E.,
Benton E.,
Robson A.,
Bhogal B.,
Stefanato C. M.,
McGibbon D.
Publication year - 2009
Publication title -
clinical and experimental dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.587
H-Index - 78
eISSN - 1365-2230
pISSN - 0307-6938
DOI - 10.1111/j.1365-2230.2009.03722.x
Subject(s) - bullous pemphigoid , medicine , hydrostatic pressure , dermatology , lymphatic system , lymphedema , autoimmunity , pathology , antibody , immunology , cancer , physics , breast cancer , thermodynamics
Summary We report a case of localized bullous pemphigoid (BP) in a woman patient with primary lymphoedema tarda. There is only one previous case reported of localized pemphigoid in an area of lymphoedema, this being of the cicatricial variant. Slow circulation in the lymphatic vessels, increased capillary permeability with preferential localization of antibodies in the area, and potential cleavage of the epidermal junction due to increased hydrostatic pressure leading to autoimmunity, have all been advocated as possible pathogenic mechanisms. Nevertheless, we consider that the mechanism by which localized pemphigoid arises on lymphoedema remains elusive, based on a previous case of generalized BP sparing an area of postsurgical lymphoedema.