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Clopidogrel: mechanisms of action and review of the evidence relating to use during skin surgery procedures
Author(s) -
Stewart L. C.,
Langtry J. A. A.
Publication year - 2010
Publication title -
clinical and experimental dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.587
H-Index - 78
eISSN - 1365-2230
pISSN - 0307-6938
DOI - 10.1111/j.1365-2230.2009.03539.x
Subject(s) - medicine , clopidogrel , warfarin , aspirin , perioperative , nonsteroidal , heparin , anesthesia , intensive care medicine , surgery , pharmacology , atrial fibrillation
Summary Patients who have skin surgery may be taking medication that increases the likelihood of bleeding, such as clopidogrel, aspirin, warfarin, heparin and nonsteroidal anti‐inflammatory drugs (NSAIDS). All of these may increase the risk of perioperative and postoperative bleeding. This article examines the mechanism of action of clopidogrel, current practice, and evidence for or against continuing its use during skin surgery. The mechanisms of action of aspirin, warfarin, heparin and NSAIDS will also be briefly discussed.