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Acute generalized exanthematous pustulosis induced by itraconazole: an immunological approach
Author(s) -
Cançado G. G. L.,
Fujiwara R. T.,
Freitas P. A.,
CorreaOliveira R.,
Bethony J. M.
Publication year - 2009
Publication title -
clinical and experimental dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.587
H-Index - 78
eISSN - 1365-2230
pISSN - 0307-6938
DOI - 10.1111/j.1365-2230.2009.03440.x
Subject(s) - acute generalized exanthematous pustulosis , itraconazole , medicine , pustulosis , immunology , chemokine , dermatology , drug reaction , drug eruption , drug , cytokine , pharmacology , inflammation , antifungal , arthritis , synovitis
Summary Acute generalized exanthematous pustulosis (AGEP) is an uncommon disease, which presents as a nonfollicular erythematous sterile pustular eruption. More than 90% of the cases are induced by adverse drug reactions, often triggered by anti‐infectious systemic drugs. We report a case of itraconazole‐induced AGEP in a 22‐year‐old man, with an assessment of his cytokine/chemokine production and drug‐specific cell reactivity. We found that AGEP, like other T cell‐mediated drug eruptions, alters the immunological status of the patient, probably favouring T‐cell activation, recruitment and regulation. Few cases of itraconazole‐induced AGEP have been described in the literature, and to our knowledge, this is the first report in which the cellular immunological features are assessed.