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A case of epidermolysis bullosa acquisita with unusual clinical features
Author(s) -
Furukita K.,
Ansai S.,
Hida Y.,
Kubo Y.,
Arase S.,
Hashimoto T.
Publication year - 2009
Publication title -
clinical and experimental dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.587
H-Index - 78
eISSN - 1365-2230
pISSN - 0307-6938
DOI - 10.1111/j.1365-2230.2009.03436.x
Subject(s) - epidermolysis bullosa acquisita , medicine , dermatology , pathology , dermis , direct fluorescent antibody , epidermolysis bullosa , skin biopsy , bullous pemphigoid , lupus erythematosus , biopsy , connective tissue disease , histopathological examination , autoimmune disease , antibody , immunology , disease
Summary A 30‐year‐old woman developed epidermolysis bullosa acquisita (EBA) with unusual clinical features. Initially, only prurigo‐like nodules were seen, which lasted for > 2 years and then blisters appeared. Eruptions resembling the rash in systemic lupus erythematosus were also seen on the face. Histopathological examination of a biopsy specimen revealed subepidermal blisters containing eosinophils and neutrophils. Direct immunofluorescence examination, indirect immunofluorescence examination using skin split with 1 mol/L sodium chloride, and immunoblotting analysis using extracts of normal human dermis gave results compatible with EBA. This case shows that EBA can present with nodular lesions as seen in pemphigoid nodularis or epidermolysis bullosa pruriginosa.