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Nasal‐type extranodal natural killer/T‐cell lymphoma presenting with extensive leg ulcers
Author(s) -
Chia H. Y.,
Tey H. L.,
Tan K. B.,
Chong W. S.
Publication year - 2009
Publication title -
clinical and experimental dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.587
H-Index - 78
eISSN - 1365-2230
pISSN - 0307-6938
DOI - 10.1111/j.1365-2230.2009.03428.x
Subject(s) - cd30 , medicine , lymphoma , natural killer t cell , pathology , cytotoxic t cell , cd5 , natural killer cell , etoposide , t cell lymphoma , granzyme , immunohistochemistry , epstein–barr virus , granzyme b , cd8 , antigen , chemotherapy , virus , immunology , biology , perforin , biochemistry , in vitro
Summary Primary cutaneous T‐cell lymphomas are rare and can be difficult to classify precisely. We present a case of extranodal natural killer (NK)/T‐cell lymphoma in a previously healthy, immunocompetent man who presented with extensive necrotic leg ulcers and disseminated skin nodules. Immunohistochemical studies revealed that the tumour cells were positive for CD3, CD30, granzyme B and T‐cell intracellular antigen‐1, and negative for CD5 and CD56, with positive staining for Epstein–Barr virus (EBV) RNA on in situ hybridization. A diagnosis of extranodal NK/T‐cell lymphoma was made, based on the presence of cytotoxic granules and positive EBV RNA staining. The patient was treated with a regimen of chemotherapy comprising corticosteroids, intravenous methotrexate, ifosphamide, L‐asparginase and etoposide with initial response.