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Hypereosinophilic syndrome in an atopic patient
Author(s) -
Neve S.,
Beukers S.,
Kirtschig G.
Publication year - 2009
Publication title -
clinical and experimental dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.587
H-Index - 78
eISSN - 1365-2230
pISSN - 0307-6938
DOI - 10.1111/j.1365-2230.2009.03356.x
Subject(s) - hypereosinophilia , eosinophilia , hypereosinophilic syndrome , medicine , atopy , dermatology , organ dysfunction , immunology , immunopathology , sepsis
Summary Hypereosinophilic syndrome (HES) is a rare, heterogeneous group of systemic diseases characterized by sustained overproduction of eosinophils leading to variable end‐organ damage. The skin is affected in 45–60% of patients and may be of diagnostic and prognostic value. In 1975, three criteria were suggested for the diagnosis of HES: (i) blood eosinophilia of > 1.5 × 10 9 /L present for > 6 months, (ii) no apparent cause for the hypereosinophilia, and (iii) signs of end‐organ dysfunction. We present a patient with hypereosinophilia in whom a delay in diagnosing HES occurred, partly due to his atopic constitution. However, atopy is not associated with such high or longstanding eosinophilia.