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Malignant amelanotic melanoma developing from an intradermal naevus in a patient with oculocutaneous albinism
Author(s) -
Wu C. Y.,
Gao H. W.,
Chiang C. P.
Publication year - 2009
Publication title -
clinical and experimental dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.587
H-Index - 78
eISSN - 1365-2230
pISSN - 0307-6938
DOI - 10.1111/j.1365-2230.2009.03261.x
Subject(s) - dermatology , medicine , oculocutaneous albinism , chiang mai , albinism , family medicine , history , paleontology , ethnology , biology
Summary A 43‐year‐old Taiwanese man who had oculocutaneous albinism type 1 presented with a tumorous lesion over the pubic region. Within the tumour, there was a small pinkish plaque. Histopathologically, the tumour revealed benign naevus cells in the upper dermis and atypical malignant tumour cells in the deeper dermis. Immunohistochemistry using HMB‐45 showed intensive positive staining in the deeper dermal tumour cells. Amelanotic malignant melanoma (MM) originating from a pre‐existing intradermal naevus was diagnosed.