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Neonatal haemangiomatosis associated with placental chorioangiomas: report of three cases and review of the literature
Author(s) -
Hoeger P. H.,
Maerker J. M.,
Kienast A. K.,
Syed S. B.,
Harper J. I.
Publication year - 2009
Publication title -
clinical and experimental dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.587
H-Index - 78
eISSN - 1365-2230
pISSN - 0307-6938
DOI - 10.1111/j.1365-2230.2009.03221.x
Subject(s) - polyhydramnios , amniocentesis , medicine , pathogenesis , placenta , obstetrics , placenta diseases , embolization , pregnancy , fetus , pathology , surgery , prenatal diagnosis , biology , genetics
Summary We report three cases of neonatal haemangiomatosis associated with large placental chorioangioma. Pregnancies were complicated by polyhydramnios, and all mothers underwent amniocentesis to drain the liquid. Steroid treatment was required for two children. Although the theory has been largely disproved in normal haemangiomas, embolization of precursor endothelial cells derived from placental vessels is a likely explanation for the pathogenesis of haemangiomatosis associated with large placental chorioangiomas.