Premium
Lesions of pemphigus vulgaris on irradiated skin
Author(s) -
Aguado L.,
Marquina M.,
Pretel M.,
RuizCarrillo G.,
España A.
Publication year - 2009
Publication title -
clinical and experimental dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.587
H-Index - 78
eISSN - 1365-2230
pISSN - 0307-6938
DOI - 10.1111/j.1365-2230.2008.03084.x
Subject(s) - pemphigus vulgaris , medicine , desmoglein 3 , pemphigus , dermatology , autoantibody , radiation therapy , autoimmune disease , desmoglein 1 , oral mucosa , skin lesion , pathology , disease , antibody , surgery , immunology
Summary Pemphigus vulgaris (PV) is an autoimmune blistering disease produced by IgG autoantibodies against desmoglein (Dsg)3. Lesions on the skin and mucosa can, in rare cases, be induced by radiotherapy. We report a patient with a history of microprolactinoma and PV, who had only oral lesions from the beginning of her illness but 2 months after treatment with radiotherapy for a breast neoplasia, developed skin lesions limited to the irradiated area. Over the following few months, she also developed autoantibodies against Dsg1.