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Urticaria pigmentosa associated with acute stress and lesional skin mast‐cell expression of CRF‐R1
Author(s) -
Theoharides T. C.,
Kempuraj D.,
Marchand J.,
Tzianoumis L.,
Vasiadi M.,
KatsarouKatsari A.,
Makris M.,
Kalogeromitros D.
Publication year - 2009
Publication title -
clinical and experimental dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.587
H-Index - 78
eISSN - 1365-2230
pISSN - 0307-6938
DOI - 10.1111/j.1365-2230.2008.03043.x
Subject(s) - urticaria pigmentosa , mast cell , medicine , immunohistochemistry , anxiety , biopsy , lesion , skin biopsy , state trait anxiety inventory , pathology , immunology , psychiatry
Summary A 38‐year‐old woman presented with a pronounced increase in symptoms and proliferation of urticaria pigmentosa (UP) after acute psychological stress, which was quantified using the Spielberger’s State–Trait Anxiety Inventory. Immunohistochemical examination of a skin biopsy from a new UP lesion showed a large number of activated mast cells expressing corticotrophin‐releasing factor receptor‐1 (CRF‐R1) and there was high serum CRF. This is the first documented report to our knowledge of UP worsening associated with acute stress, possibly through activation of skin mast‐cell CRF‐R1.