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Disseminated cutaneous histoplasmosis in acquired immunodeficiency syndrome: report of 23 cases
Author(s) -
Bonifaz A.,
Chang P.,
Moreno K.,
FernándezFernández V.,
Montes de Oca G.,
Araiza J.,
Ponce R. M.
Publication year - 2009
Publication title -
clinical and experimental dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.587
H-Index - 78
eISSN - 1365-2230
pISSN - 0307-6938
DOI - 10.1111/j.1365-2230.2008.02974.x
Subject(s) - histoplasmosis , medicine , itraconazole , dermatology , amphotericin b , mycosis , surgery , antifungal
Summary Disseminated cutaneous histoplasmosis is an opportunistic infection in patients with acquired immunodeficiency syndrome. We report a series of 23 cases (21 men, two women; median age 29 years) with disseminated cutaneous histoplasmosis seen at two hospital centres. Most of the patients (21/23) were classified as stage C3. The most common dermatological findings were papules, crusting plaques, nodules and ulcers, mainly located on the face and chest. Of the 23 cases, 15 (65%) had pulmonary involvement. Amphotericin B and itraconazole were the main drugs used for treatment. Treatment response was variable: four of the patients were cured, six improved and remain stable, nine patients died, and four patients were lost to follow‐up.