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Rowell’s syndrome in the course of treatment with sodium valproate: a case report and review of the literature data
Author(s) -
KacalakRzepka A.,
Kiedrowicz M.,
BieleckaGrzela S.,
RatajczakStefanska V.,
Maleszka R.,
Mikulska D.
Publication year - 2009
Publication title -
clinical and experimental dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.587
H-Index - 78
eISSN - 1365-2230
pISSN - 0307-6938
DOI - 10.1111/j.1365-2230.2008.02972.x
Subject(s) - toxic epidermal necrolysis , erythema multiforme , sertraline , medicine , dermatology , prednisolone , valproic acid , erythema , epilepsy , pediatrics , psychiatry , anxiety , antidepressant
Summary Rowell’s syndrome (RS) is a rare type of coexistence of one of the lupus erythematosus (LE) types (systemic, subacute cutaneous or discoid) and erythema multiforme (EM) (including toxic epidermal necrolysis). We present the case of a 51‐year‐old patient with a diagnosis of RS, most probably caused by drugs given as psychiatric treatment. After cessation of sodium valproate and initiation of treatment with prednisolone, a spectacular clinical remission was achieved. The likely role of psychiatric drugs, namely sodium valproate and sertraline, as triggering factors, is discussed.