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The Leser–Trélat sign is associated with nasopharyngeal carcinoma: case report and review of cases reported in China
Author(s) -
Li M.,
Yang L.J.,
Zhu X.H.,
Zhang Y.S.,
Sun H.,
Jiang P.D.,
Zhang R.R.,
Tang W.,
Cai Y.
Publication year - 2009
Publication title -
clinical and experimental dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.587
H-Index - 78
eISSN - 1365-2230
pISSN - 0307-6938
DOI - 10.1111/j.1365-2230.2008.02923.x
Subject(s) - medicine , nasopharyngeal carcinoma , malignancy , radiology , sign (mathematics) , dermatology , biopsy , carcinoma , radiation therapy , pathology , mathematical analysis , mathematics
Summary The sign of Leser–Trélat (LT) is defined as the sudden eruption of multiple seborrhoeic keratoses (SKs), or increase in the number and size of existing SKs, associated with an underlying malignancy. A 75‐year‐old man was admitted to our hospital with dyspnoea and multiple verrucous papules that had been developing gradually over the previous 30 years. During the 3 months before presentation, the number of SKs on his chest and back had increased rapidly. A diagnosis of nasopharyngeal carcinoma was made based on results of computed tomography, endoscopy and biopsy examinations. The patient is receiving radiotherapy at present. To our knowledge, this is the first case of the Leser–Trélat sign associated with nasopharyngeal carcinoma.