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Lichen planus pemphigoides associated with Chinese herbs
Author(s) -
Xu H.H.,
Xiao T.,
He C.D.,
Jin G.Y.,
Wang Y.K.,
Gao X.H.,
Chen H.D.
Publication year - 2009
Publication title -
clinical and experimental dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.587
H-Index - 78
eISSN - 1365-2230
pISSN - 0307-6938
DOI - 10.1111/j.1365-2230.2008.02900.x
Subject(s) - dermatology , medicine , chinese herbs , pathology , traditional chinese medicine , alternative medicine
Summary We report a 62‐year‐old Chinese woman with a 2‐year history of lichen planus presenting with extensive violaceous maculopapules and plaques 1 week after taking an oral preparation of Chinese herbs. The patient developed vesiculobullous skin lesions 7 weeks later. Histopathological examination showed subepidermal blisters and adjacent bandlike lymphocytic infiltration. Direct immunofluorescence revealed linear deposits of IgG and C3 along the basement membrane zone. Indirect immunofluorescence showed IgG antibody deposition along the epidermal side of salt‐split human skin. Circulating anti‐bullous pemphigoid 180 antibodies were detected by ELISA. Lichen planus pemphigoides (LPP) was diagnosed. To our knowledge, this is the first report of LPP associated with oral Chinese herbs.