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Beyond flat weals: validation of a three‐dimensional imaging technology that will improve skin allergy research
Author(s) -
Dos Santos R. V.,
Mlynek A.,
Lima H. C.,
Martus P.,
Maurer M.
Publication year - 2008
Publication title -
clinical and experimental dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.587
H-Index - 78
eISSN - 1365-2230
pISSN - 0307-6938
DOI - 10.1111/j.1365-2230.2008.02897.x
Subject(s) - medicine , dermatology , allergy , medical physics , immunology
Summary Skin‐prick tests (SPTs) are a standard way to test for sensitizations to allergens, but to date, techniques that allow for high‐quality measurements of the resulting weals for research purposes are lacking. In this study, we assessed a new three‐dimensional (3D) imaging technology for its accuracy and consistency. We found that this new technology showed very little intraoperator and interoperator variation for repeated measurements of a model of known area by each of two operators. We also found that repeated measurements of the same object over 4 months showed virtually no variation. Finally, 3D imaging was superior to traditional ruler measurements for assessing SPT reactions to histamine and allergen. For high‐quality measurements of SPT reactions, 3D imaging is accurate, consistent and reliable.