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Recurrent bullous lesions associated with familial Mediterranean fever: a case report
Author(s) -
Akman A.,
Cakcak D. S.,
Coban E.,
Ozbudak H. I.,
Ciftcioglu M. A.,
Alpsoy E.,
Yilmaz E.
Publication year - 2009
Publication title -
clinical and experimental dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.587
H-Index - 78
eISSN - 1365-2230
pISSN - 0307-6938
DOI - 10.1111/j.1365-2230.2008.02884.x
Subject(s) - medicine , lesion , dermatology , familial mediterranean fever , erythema , skin biopsy , abdominal pain , erythema nodosum , biopsy , pathology , disease , surgery
Summary Familial Mediterranean fever (FMF) is an inherited, recurrent, inflammatory disease. Of its various cutaneous features, erysipelas‐like erythema is the best known and most common skin lesion. We present a new case of FMF with recurrent bullous lesions. A 41‐year‐old woman was admitted to our clinic with tense bullae, 20 × 20 mm in diameter on the left shin. The patient had a history of fever, abdominal pain, peritonitis attacks and infertility. A lesional skin biopsy revealed subepidermal bullae and neutrophilic infiltration around dermal vessels. Direct immunofluorescence analysis was negative. Over the period of investigation, the lesion regressed spontaneously; 1 month later, a similar lesion appeared on the right wrist. Diagnosis of FMF was made according to the Tel‐Hashomer criteria. Recognition of this peculiar skin lesion may lead to an earlier diagnosis of the disease.