Premium
Pseudolymphomatous angiokeratoma: report of three cases and an immunohistological study
Author(s) -
Okuyama R.,
Masu T.,
Mizuashi M.,
Watanabe M.,
Tagami H.,
Aiba S.
Publication year - 2009
Publication title -
clinical and experimental dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.587
H-Index - 78
eISSN - 1365-2230
pISSN - 0307-6938
DOI - 10.1111/j.1365-2230.2008.02849.x
Subject(s) - pathology , medicine , cd20 , cd3 , immunohistochemistry , angiokeratoma , cd8 , antigen , immunology
Summary Background. Pseudolymphomatous angiokeratoma (PA), originally termed ‘acral pseudolymphomatous angiokeratoma of children’, is a disorder characterized clinically by development of red nodules on the extremities and histologically by a subepidermal dense lymphocyte infiltrate. Methods. We report three cases of PA, with characteristically dense, nodular infiltrate composed predominantly of small lymphocytes, and thick‐walled vessels. Results. Immunohistochemical investigation revealed a dense accumulation of CD20+ cells with CD3+ cells in one case. Infiltrate in the other two cases was mainly composed of CD3+ cells and a mixture of CD4+ and CD8+ cells, with a few cells expressing CD20. Conclusion. Our immunohistological results reveal a wide spectrum of cellular infiltrate compositions ranging from T‐cell to B‐cell predominance.