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Cutaneous dissemination of nasal NK/T‐cell lymphoma in a young girl
Author(s) -
Sandner A.,
Helmbold P.,
Winkler M.,
Gattenlöhner S.,
MüllerHermelink H.K.,
Holzhausen H.J.
Publication year - 2008
Publication title -
clinical and experimental dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.587
H-Index - 78
eISSN - 1365-2230
pISSN - 0307-6938
DOI - 10.1111/j.1365-2230.2008.02777.x
Subject(s) - lymphoma , medicine , t cell lymphoma , pathology , epstein–barr virus , virus , dermatology , pathological , immunology
Summary In Europe and the USA, the incidence of primary nasal natural killer (NK)/T‐cell lymphoma is rare. The skin is one of the predilection sites for dissemination. Cutaneous dissemination is a poor prognostic sign and is consistently fatal. We describe the case of a 17‐year‐old white German girl with a primary nasal NK/T‐cell lymphoma and cutaneous dissemination. She presented with multiple maculopapular patches involving the trunk and thighs, and a 4‐week history of headache, fever and fatigue. Biopsies of the skin and the nasal mucosa were taken. Pathological examination of both specimens revealed a NK/T‐cell lymphoma. Epstein–Barr virus RNA was detected in the lymphoma cells by in situ hybridization. Unfortunately, the patient died of disease within 1 week.