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Indeterminate cell histiocytosis successfully treated with ultraviolet B phototherapy
Author(s) -
Ishibashi M.,
Ouchi T.,
Tanikawa A.,
Ishiko A.
Publication year - 2008
Publication title -
clinical and experimental dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.587
H-Index - 78
eISSN - 1365-2230
pISSN - 0307-6938
DOI - 10.1111/j.1365-2230.2007.02667.x
Subject(s) - birbeck granules , medicine , langerhans cell histiocytosis , biopsy , skin biopsy , infiltration (hvac) , dermatology , histiocytosis , pathology , histiocyte , langerhans cell , disease , physics , antigen , immunology , thermodynamics
Summary Indeterminate cell histiocytosis (ICH) is a rare disorder, characterized by infiltration of the skin by neoplastic cells that are characteristically positive for S‐100 and CD1a, but lack Birbeck's granules. A 75‐year‐old man presented with a 4‐year history of multiple papules on the trunk, limbs, face and neck. Skin biopsy revealed dense infiltration of histiocytic cells that were CD1a+/S100+, but lacked Birbeck's granules. No other abnormality was seen during a general examination including a computed tomography scan of the body, gallium scintigraphy, and an abdominal sonography. Broadband ultraviolet B (UVB) treatment was used for the skin lesions, and partial but almost complete remission was obtained. The case suggests that UVB phototherapy is an option for treatment of ICH.