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Intralesional triamcinolone alone or in combination with 5‐fluorouracil for the treatment of keloid and hypertrophic scars
Author(s) -
Darougheh A.,
Asilian A.,
Shariati F.
Publication year - 2009
Publication title -
clinical and experimental dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.587
H-Index - 78
eISSN - 1365-2230
pISSN - 0307-6938
DOI - 10.1111/j.1365-2230.2007.02631.x
Subject(s) - medicine , dermatology , cutaneous leishmaniasis , triamcinolone acetonide , keloid , family medicine , leishmaniasis , surgery , pathology
Summary Background. Keloids and hypertrophic scars are benign growths of dermal collagen that can cause physical and psychological (cosmetic) problems for patients. Methods. In this 12‐week, double‐blind, clinical trial, 40 patients were randomized into two study groups. Patients in group 1 were given intralesional triamcinolone acetonide (TAC), and patients in group 2 were given a combination of TAC and 5‐fluorouracil (5‐FU); both groups received injections at weekly intervals for 8 weeks. Lesions were assessed for erythema, pruritus, pliability, height, length and width. Results. Four patients in group 1 and three patients in group 2 failed to complete the study. At the 8‐week and 12‐week follow‐up visits, both groups showed an acceptable improvement in nearly all parameters, but these were more significant in the TAC + 5‐FU group ( P < 0.05 for all except pruritus and percentage of itch reduction). Good to excellent (> 50%) improvement were reported by 20% of the patients in group 1 and 55% of the patients in group 2, which was significantly different ( P = 0.02). Good to excellent responses was reported by trained observers as 15% in group 1 and 40% in group 2. Their difference was not significant ( P = 0.08). Conclusion. The overall efficacy of TAC + 5‐FU was comparable with TAC, but the TAC + 5‐FU combination was more acceptable to patients and produced better results.