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Association of the interleukin‐10 distal promoter (‐2763A/C) polymorphism with late‐onset psoriasis
Author(s) -
Wongpiyabovorn J.,
Hirankarn N.,
Ruchusatsawat K.,
Yooyongsatit S.,
Asawada P.,
Poovorawan Y.
Publication year - 2008
Publication title -
clinical and experimental dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.587
H-Index - 78
eISSN - 1365-2230
pISSN - 0307-6938
DOI - 10.1111/j.1365-2230.2007.02628.x
Subject(s) - psoriasis , haplotype , single nucleotide polymorphism , allele , allele frequency , medicine , genetic predisposition , population , immunology , genotype , gastroenterology , genetics , biology , gene , disease , environmental health
Summary Polymorphisms of the IL‐10 promoter have been implicated in the genetic susceptibility to many autoimmune diseases, including psoriasis. Four putative functional single‐nucleotide polymorphisms (SNPs) within the interleukin‐10 promoter region (−3575T/A, −2763A/C, −1082G/A and −592C/A) were analysed in 139 patients with chronic plaque psoriasis and in 155 unrelated healthy controls from Thailand. There were no significant differences in the allele frequencies of any of the four SNPs between patients with psoriasis and controls. However, the frequency of the −2763A allele was increased in patients with late‐onset psoriasis compared with controls and patients with early‐onset psoriasis [OR = 2.94, 95% CI 1.16–7.39, corrected P value ( Pc ) = 0.04 and OR = 3.26, 95% CI 1.13–9.51, Pc = 0.048, respectively]. The AAGC (−3575/−2763/−1082/−592) haplotype frequency was higher in late‐onset compared with early onset psoriasis (OR = 4.37, 95% CI 1.24–15.97, Pc = 0.027). This study suggests that the −2763A allele and the extended AAGC haplotype can be used as a genetic marker for susceptibility to late‐onset psoriasis in a Thai population.