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Severe deterioration of psoriasis due to an insulinoma
Author(s) -
Field S.,
Kelly G.,
Tobin A.M.,
Barragry J. M.,
Conlon K. C.,
Kirby B.
Publication year - 2008
Publication title -
clinical and experimental dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.587
H-Index - 78
eISSN - 1365-2230
pISSN - 0307-6938
DOI - 10.1111/j.1365-2230.2007.02578.x
Subject(s) - insulinoma , psoriasis , medicine , dermatology , intensive care medicine , insulin
Summary We report a case of a 56‐year‐old woman who presented with a severe exacerbation of psoriasis with concurrent hypoglycaemic episodes. Methotrexate 17.5 mg weekly was required to control her psoriasis. Investigation of her hypoglycaemia showed raised levels of insulin, C‐peptide and proinsulin. Radiological investigation showed a tumour at the tail of the pancreas and the diagnosis was insulinoma. A spleen‐preserving distal pancreatectomy was performed and the hypoglycaemic symptoms resolved. Immediately following the pancreatectomy, methotrexate was stopped and the patient’s psoriasis went into remission. During a 2‐year follow‐up, she has required only minimal topical treatment for her skin.