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The effect of vitamin E on acute skin reaction caused by radiotherapy
Author(s) -
Dirier A.,
Akmansu M.,
Bora H.,
Gurer M.
Publication year - 2007
Publication title -
clinical and experimental dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.587
H-Index - 78
eISSN - 1365-2230
pISSN - 0307-6938
DOI - 10.1111/j.1365-2230.2007.02452.x
Subject(s) - ionizing radiation , erythema , vitamin e , skin reaction , medicine , vitamin , radiation therapy , irradiation , necrosis , carcinogen , antioxidant , vitamin c , dermatology , pathology , cancer research , chemistry , biochemistry , physics , nuclear physics
Summary Ionizing radiation affects healthy organs and tissues as well as diseased tissues during radiation therapy. Skin reactions varying from acute erythema to necrosis can be seen. It has been found that vitamin E can prevent mutagenic and/or carcinogenic effects of ionizing radiation in both animals and cell cultures. This study investigated the preventative effect of antioxidant vitamin E on irradiation‐induced acute skin reactions. No protective effect of vitamin E was demonstrated. It is possible that the vehicle induced free radical exposure in the irradiated skin.