Premium
Association of HLA‐DRB1*16 with chronic discoid lupus erythematosus in Mexican mestizo patients
Author(s) -
LópezTello A.,
RodríguezCarreón A.A.,
Jurado F.,
YamamotoFurusho J. K.,
CastilloVázquez M.,
ChávezMuñoz C.,
Salgado N.,
ArellanoCampos O.,
VargasAlarcón G.,
Granados J.
Publication year - 2007
Publication title -
clinical and experimental dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.587
H-Index - 78
eISSN - 1365-2230
pISSN - 0307-6938
DOI - 10.1111/j.1365-2230.2007.02391.x
Subject(s) - medicine , discoid lupus erythematosus , dermatology , lupus erythematosus , association (psychology) , immunology , antibody , psychology , psychotherapist
Summary Background. Chronic discoid lupus erythematosus (CDLE) is present in 15–30% of patients with systemic lupus erythematosus (SLE). Approximately 5% of CDLE cases can evolve to SLE at some stage of the disease. Aim. The aim of this study was to determine gene frequencies of HLA‐DRB1 alleles in Mexican mestizo patients with CDLE, irrespective of the presence of systemic disease. Methods. The study comprised 28 Mexican mestizo patients with CDLE who were attending the Passover Dermatology Centre, in Mexico City. HLA‐DRB1 and DQ allele typing was performed by sequence‐specific oligotyping after DNA amplification using PCR. The study also included 99 ethnically matched healthy individuals as controls. Results. In the patient group, a significantly increased gene frequency was found for the HLA‐DR4 ( P = 0.016, OR = 2.24, 95% CI 1.14–4.38) and HLA‐DR16 alleles ( P = 0.005, OR = 5.51, 95% CI 1.49–21.08). Conclusion. HLA‐DRB1 alleles seem to be involved in the genetic susceptibility to CDLE in the Mexican mestizo population.