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Vulval intraepithelial neoplasia and periungual Bowen's disease concordant for mucosal (HPV‐34) and epidermodysplasia verruciformis (HPV‐21) human papillomavirus types
Author(s) -
EkeowaAnderson A. L.,
Harwood C. A.,
Perrett C. M.,
Sahota A.,
Annan H.,
Ran H.,
Leigh I. M.,
Gibbon K. L.
Publication year - 2007
Publication title -
clinical and experimental dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.587
H-Index - 78
eISSN - 1365-2230
pISSN - 0307-6938
DOI - 10.1111/j.1365-2230.2007.02388.x
Subject(s) - epidermodysplasia verruciformis , medicine , human papillomavirus , obstetrics and gynaecology , dermatology , family medicine , biology , genetics , pregnancy
Summary Human papillomavirus (HPV) infection is associated with genital malignancy and specific cutaneous malignancies. We report a case of an HPV‐associated concurrent vulval intraepithelial neoplasia and periungual Bowen's disease in a young immunocompetent Afro‐Caribbean woman with no known risk factors for either disease. HPV genotyping studies detected multiple α and β papillomaviruses with concordance for HPV‐34 [a high‐risk (HR) mucosal type], and HPV‐21 [an epidermodyslasia verruciformis (EV) type] in both vulval and finger tissue. Although the HR‐mucosal viruses detected are likely to have a pathogenic role in vulval intraepithelial neoplasia, this is the first report of concordance for EV HPV types in both genital and nongenital skin premalignancies. This case, in the context of accumulating epidemiological and experimental data in cutaneous SCC, raises the question of whether EV HPV may contribute to vulval malignancy, and further study is merited.