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Successful treatment of lichen amyloidosis with combined bath PUVA photochemotherapy and oral acitretin
Author(s) -
Grimmer J.,
Weiss T.,
Weber L.,
Meixner D.,
ScharffetterKochanek K.
Publication year - 2007
Publication title -
clinical and experimental dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.587
H-Index - 78
eISSN - 1365-2230
pISSN - 0307-6938
DOI - 10.1111/j.1365-2230.2006.02244.x
Subject(s) - acitretin , dermatology , puva therapy , medicine , psoriasis
Summary Lichen amyloidosis (LA) is a chronic, pruritic skin disorder characterized by brownish‐grey papules on extensor surfaces of legs and rarely on the trunk. Thioflavin T‐positive amyloid deposits are found in the papillary dermis of affected skin, which is the only organ involved. A variety of therapeutic regimens for lichen amyloidosis have been described; however, in many cases with only limited effect. We report on two patients with lichen amyloidosis with typical clinical symptoms not responding to local treatment. A combined regimen with bath psoralen ultraviolet A (PUVA) and oral acitretin was initiated, resulting in nearly complete resolution of the papules and impressive relief from the severe pruritus. The beneficial response has persisted for 8 months. The suggested combined therapy with bath PUVA photochemotherapy and oral acitretin represents an efficacious and practical treatment modality for lichen amyloidosis with long‐lasting effects.