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Histiocytoid eccrine sweat gland carcinoma of the eyelid: report of a case
Author(s) -
Swinson B.,
Ryan F.,
Barrett A. W.,
Jerjes W.,
Landon G.,
Calonje E.,
Kalavrezos N.
Publication year - 2006
Publication title -
clinical and experimental dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.587
H-Index - 78
eISSN - 1365-2230
pISSN - 0307-6938
DOI - 10.1111/j.1365-2230.2006.02231.x
Subject(s) - sweat gland , pathology , medicine , signet ring cell , eccrine sweat gland , eyelid , metastasis , eosinophilic , neoplasm , eccrine sweat , perineural invasion , anatomy , adenocarcinoma , sweat , cancer , radiology
Summary This report describes the 12th documented case of histiocytoid, diffuse or signet‐ring cell eccrine sweat gland carcinoma of the eyelid, a rare neoplasm that characteristically affects older men and mimics distant metastasis. Clinically, the patient was thought to have a colonic metastasis. Histologically, the neoplasm comprised sheets and cords of polygonal, eosinophilic cells, with dispersed larger, rounded single cells resembling histiocytes, and cells with cytoplasmic lumina or a signet‐ring appearance. Occasional duct formation was also seen. The features were reminiscent of both the histiocytoid and lobular variants of breast carcinoma. Ultrastructurally, the presence of nonintestinal type microvilli with a length : width ratio in excess of 16 were consistent with an eccrine origin, but also raised the possibility of metastatic mesothelioma. However, a metastatic lesion was excluded by clinical and imaging investigations. There has been no recurrence 3 years after primary excision.