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Epidermodysplasia verruciformis and generalized verrucosis: the same disease?
Author(s) -
Yanagi T.,
Shibaki A.,
TsujiAbe Y.,
Yokota K.,
Shimizu H.
Publication year - 2006
Publication title -
clinical and experimental dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.587
H-Index - 78
eISSN - 1365-2230
pISSN - 0307-6938
DOI - 10.1111/j.1365-2230.2006.02100.x
Subject(s) - epidermodysplasia verruciformis , differential diagnosis , dermatology , medicine , actinic keratosis , genodermatosis , human papilloma virus , skin lesion , abnormality , pathology , cancer , virus , virology , cervical cancer , biology , biochemistry , basal cell , psychiatry , gene
Summary We report a patient with epidermodysplasia verruciformis (EV) who had severe generalized verrucous skin lesions for 50 years without any immunological abnormality. Microscopic examination showed two histopathological features, including seborrhoeic keratosis and common warts. The detected human papilloma virus (HPV) types were found to be HPV 3, 50, 5, and 76, using a degenerate PCR method. EV and generalized verrucosis are distinguished by slight differences in clinical symptoms or HPV types, so there should be no apparent differential points common to both diseases. Therefore, we propose that an abnormal susceptibility specific to HPV, which is the most characteristic feature in EV, should be regarded as a differential point in these two diseases.