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A case of Rothmann–Makai panniculitis successfully treated with tetracycline
Author(s) -
Asano Y.,
Idezuki T.,
Igarashi A.
Publication year - 2006
Publication title -
clinical and experimental dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.587
H-Index - 78
eISSN - 1365-2230
pISSN - 0307-6938
DOI - 10.1111/j.1365-2230.2005.02055.x
Subject(s) - minocycline , tetracycline , clarithromycin , medicine , panniculitis , antibiotics , erythromycin , tetracycline hydrochloride , dermatology , gastroenterology , trunk , microbiology and biotechnology , helicobacter pylori , ecology , biology
Summary Rothmann–Makai syndrome (lipogranulomatosis subcutanea) is a rare variant of Weber–Christian disease, but lacks visceral involvements and systemic manifestations. We herein report the case of a 56‐year‐old Chinese woman with this disorder who complained of subcutaneous tender nodules over her extremities, trunk, and face of 2 years' duration. She was firstly treated with 300 mg of oral roxythromycin for 8 weeks and subsequently treated with 400 mg of oral clarithromycin for the next 8 weeks. However, no significant effect was observed. She was then administered 200 mg of oral minocycline hydrochloride. After 1 week, her skin symptoms rapidly improved and no relapse has been observed in a follow‐up period of 3 months. Considering that tetracycline antibiotics, but not macrolide antibiotics, inhibit the activity of pancreatic lipase in vitro , the efficiency of tetracycline antibiotics may be a clue to clarifying the pathogenesis of this disorder.